EME1
Product Specifications
Gene Name
[EME1]
NCBI Gene ID
146956
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.<br>Antibody without azide: store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Essential meiotic endonuclease 1 (Eme1), a member of the Eme1/Mms4 family, associates with Mus81 to constitute a heterodimeric endonuclease that has been implicated in mitotic and meiotic recombination in eukaryotes. The Mus81-Eme1 complex cleaves branched DNA structures, especially those arising during stalled DNA replication such as replication forks and 3 DNA flaps. When purified from yeast, this complex cleaves synthetic Holliday junctions into linear duplex DNA. These findings provide compelling evidence that Mus81-Eme1 complexes are essential elements of the eukaryotic nuclear Holliday junction resolvase. Eme1 may also be required in mitosis for the processing of collapsed replication forks. Eme1 is typically localized to the nucleolus and is recruited to regions of DNA damage in S phase cells.
Other Gene Names
[EME1; EME1; MMS4L; SLX2A; MMS4; hMMS4]
Short Name
[EME1]
Other Product Names
[crossover junction endonuclease EME1 isoform 1; Crossover junction endonuclease EME1; crossover junction endonuclease EME1; essential meiotic structure-specific endonuclease 1; MMS4 homolog]
NCBI GI Number
260763969
NCBI Accession Number
NP_001159603.1
NCBI GB Accession Number
NP_001159603.1
Uniprot Accession Number
Q96AY2
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
