CD103/Integrin alpha E beta7 (T-Cell Lymphoma Hairy Cell Leukemia Marker)

Product Specifications

Gene Name

[ITGAE]

NCBI Gene ID

3682

Reactivity

Human

Storage Conditions

Antibody with azide: store at 2 to 8 degree C.<br>Antibody without azide: store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Specificity

This MAb recognizes a protein of 150kDa, identified as CD103, which is the alpha-E integrin subunit of the heterodimeric alpha-E beta-7 (aEb7) integrin belonging to a small beta-7 integrin subfamily. CD103 is expressed on more than 95% of intraepithelial CD8+ cells and on 40% of mucosa-associated T cells, whereas less than 2% of resting blood lymphocytes are CD103-positive. In several malignant conditions, such as T-cell lymphomas and hairy cell leukemia (HCL), the cells express CD103. Antibody to CD103 is an extremely useful addition to the IHC panel for the identification of hairy cell leukemia (HCL).

Other Gene Names

[ITGAE; ITGAE; CD103; HUMINAE]

Short Name

[CD103/Integrin alpha E beta7]

Other Product Names

[Integrin alpha-E; Integrin alpha-E; integrin alpha-E; integrin subunit alpha E; HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; CD_antigen: CD103Cleaved into the following 2 chains:Integrin alpha-E light chain; Integrin alpha-E heavy chain]