CD45/LCA (B-Cell Marker)
Product Specifications
Gene Name
[PTPRC]
NCBI Gene ID
5788
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.<br>Antibody without azide: store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential identification of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.
Other Gene Names
[PTPRC; PTPRC; LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; CD45; L-CA]
Short Name
[CD45/LCA]
Other Product Names
[receptor-type tyrosine-protein phosphatase C isoform 1; Receptor-type tyrosine-protein phosphatase C; receptor-type tyrosine-protein phosphatase C; protein tyrosine phosphatase receptor type C; Leukocyte common antigen; L-CA; T200]
NCBI GI Number
392307007
NCBI Accession Number
NP_002829.3
NCBI GB Accession Number
NP_002829.3
Uniprot Accession Number
P08575
Available Sizes
Curated Selection
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