CD74 (B-Cell Marker)
Product Specifications
Gene Name
[CD74]
NCBI Gene ID
972
Reactivity
Human, Baboon, Mouse<br>Does not react with Rat
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.<br>Antibody without azide: store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
It recognizes a protein of ~35kDa, identified as CD74 (Workshop IV). CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).
Other Gene Names
[CD74; II; p33; DHLAG; HLADG; Ia-GAMMA]
Short Name
[CD74]
Other Product Names
[HLA class II histocompatibility antigen gamma chain; CD74 molecule]
Uniprot Accession Number
P044233
Available Sizes
Curated Selection
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