Mepazine (hydrochloride)
Product Specifications
Product Name Alternative
Pecazine (hydrochloride)
UNSPSC Description
Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis[1].
Target Antigen
Apoptosis; MALT1
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease;NF-κB
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mepazine-hydrochloride.html
Purity
99.94
Solubility
DMSO : 50 mg/mL (ultrasonic)|H2O : 2.22 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CN1CC(CN2C3=C(C=CC=C3)SC4=CC=CC=C24)CCC1.[H]Cl
Molecular Weight
346.92
References & Citations
[1]Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22(6):825-37.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121282A/Mepazine-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121282A/Mepazine-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2975-36-2
Available Sizes
Curated Selection
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