Mepazine (hydrochloride)
Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis[1].
Product Specifications
CAS Number
[2975-36-2]
Product Name Alternative
Pecazine (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; MALT1
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mepazine-hydrochloride.html
Purity
99.25
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 2.22 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN1CC(CN2C3=C(C=CC=C3)SC4=CC=CC=C24)CCC1.[H]Cl
Molecular Formula
C19H23ClN2S
Molecular Weight
346.92
Precautions
H302
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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BMAL1, acetylated (Lys538) (aryl hydrocarbon receptor nuclear translocator-like, Aryl hydrocarbon receptor nuclear translocator-like protein 1, Basic-helix-loop- helix-PAS Protein MOP3, bHLHe5, bHLH-PAS Protein JAP3, BMAL1, BMAL1c, Brain and Muscle ARNT-like 1, JAP3, Member of PAS Protein 3, MGC47515, MOP3, PASD3, TIC) (Biotin)