Mepazine (hydrochloride)

Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis[1].

Product Specifications

CAS Number

[2975-36-2]

Product Name Alternative

Pecazine (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; MALT1

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mepazine-hydrochloride.html

Purity

99.25

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 2.22 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN1CC(CN2C3=C(C=CC=C3)SC4=CC=CC=C24)CCC1.[H]Cl

Molecular Formula

C19H23ClN2S

Molecular Weight

346.92

Precautions

H302

References & Citations

[1]Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22 (6) :825-37.