Ezrin/p81
Product Specifications
Gene Name
[EZR]
NCBI Gene ID
7430
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.<br>Antibody without azide: store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Ezrin, Moesin and Radixin belong to a family of highly homologous Actinassociated proteins that are localized just beneath the plasma membrane. The proteins are believed to be involved in the mediation of interactions between cytoskeletal and membrane proteins. Ezrin serves as a major cytoplasmic substrate of various protein-tyrosine kinases, including the epidermal growth factor receptor. Ezrin has also been identified as a cAMP-dependent protein kinase (A-kinase) anchoring protein and designated AKAP78. Moesin and Radixin share over 70% homology with Ezrin and are coexpressed within various cell types. Despite the high degree of homology, the three proteins exhibit a distinct receptor-specific pattern of phosphorylation. Overexpression of Ezrin predicts the poor prognosis of gastric adenocarcinoma.
Other Gene Names
[EZR; EZR; CVL; CVIL; VIL2; HEL-S-105; VIL2]
Short Name
[Ezrin/p81]
Other Product Names
[ezrin; Ezrin; ezrin; ezrin; Cytovillin; Villin-2; p81]
NCBI GI Number
161702986
NCBI Accession Number
NP_001104547.1
NCBI GB Accession Number
NP_001104547.1
Uniprot Accession Number
P15311
Available Sizes
Curated Selection
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