Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker)
Product Specifications
Gene Name
[TYRP-1]
NCBI Gene ID
7306
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.<br>Antibody without azide: store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
Other Gene Names
[TYRP1; TYRP1; TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN; CAS2; TYRP; TYRRP; DHICA oxidase; TRP; TRP-1; TRP1]
Short Name
[Tyrosinase-Related Protein-1 (TYRP-1)]
Other Product Names
[5,6-dihydroxyindole-2-carboxylic acid oxidase; 5,6-dihydroxyindole-2-carboxylic acid oxidase; 5,6-dihydroxyindole-2-carboxylic acid oxidase; tyrosinase related protein 1; Catalase B; Glycoprotein 75; Melanoma antigen gp75; Tyrosinase-related protein 1; TRP; TRP-1; TRP1]
NCBI GI Number
4507757
NCBI Accession Number
NP_000541.1
NCBI GB Accession Number
NP_000541.1
Uniprot Accession Number
P17643
Available Sizes
Curated Selection
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