Thymidylate Synthase (5-FU Resistance Marker)
Product Specifications
Gene Name
[TYMS]
NCBI Gene ID
7298
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C. Non-hazardous. No MSDS required.
Specificity
It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Other Gene Names
[TYMS; TYMS; TS; TMS; HST422; TS; TS; TSase]
Short Name
[Thymidylate Synthase]
Other Product Names
[Thymidylate synthase; Thymidylate synthase; thymidylate synthase; thymidylate synthetase]
NCBI GI Number
136611
NCBI Accession Number
P04818.3
Uniprot Accession Number
P04818
Available Sizes
Curated Selection
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