Tal1

Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase II, a serine/threonine protein kinase known to modulate the activity of other HLH transcription factors.

[T-cell acute lymphocytic leukemia protein 1 isoform 1; T-cell acute lymphocytic leukemia protein 1; T-cell acute lymphocytic leukemia protein 1; TAL bHLH transcription factor 1, erythroid differentiation factor; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5]