Tal1
Product Specifications
Gene Name
[TAL1]
NCBI Gene ID
6886
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase II, a serine/threonine protein kinase known to modulate the activity of other HLH transcription factors.
Other Gene Names
[TAL1; TAL1; SCL; TCL5; tal-1; bHLHa17; BHLHA17; SCL; TCL5; TAL-1; bHLHa17]
Short Name
[Tal1]
Other Product Names
[T-cell acute lymphocytic leukemia protein 1 isoform 1; T-cell acute lymphocytic leukemia protein 1; T-cell acute lymphocytic leukemia protein 1; TAL bHLH transcription factor 1, erythroid differentiation factor; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5]
NCBI GI Number
4507363
NCBI Accession Number
NP_003180.1
NCBI GB Accession Number
NP_003180.1
Uniprot Accession Number
P17542
Available Sizes
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