Prohibitin (Mitochondrial Marker)
Product Specifications
Gene Name
[PHB]
NCBI Gene ID
5245
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.<br>Antibody without azide: store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Recognizes a protein of 30kDa which is identified as Prohibitin, an evolutionarily conserved protein with homologues found in yeast to man. It is located in the inner membrane of mitochondria. Although prohibitin mRNA and protein expression occurs throughout the cell cycle, maximum levels are detected during the G1/S phase transition and minimum levels are seen in S phase and the G2/mitosis boundary. Prohibitin is located exclusively in the mitochondria with the highest concentration on the inner membrane. Prohibitin is an ideal mitochondrial marker. It shows antiproliferative activity and has been proposed to play a role in normal cell cycle regulation, replicative senescence, cellular immortalization, and tumor suppression.
Other Gene Names
[PHB; PHB; PHB1; HEL-215; HEL-S-54e]
Short Name
[Prohibitin]
Other Product Names
[prohibitin; Prohibitin; prohibitin; prohibitin]
NCBI GI Number
246483
NCBI Accession Number
AAB21614.1
Uniprot Accession Number
P35232
Available Sizes
Curated Selection
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