Langerin/CD207 (Marker of Langerhans Cells)
Product Specifications
Gene Name
[CD207]
NCBI Gene ID
50489
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.<br>Antibody without azide: store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.
Other Gene Names
[CD207; CD207; CLEC4K; CLEC4K]
Short Name
[Langerin/CD207]
Other Product Names
[C-type lectin domain family 4 member K; C-type lectin domain family 4 member K; C-type lectin domain family 4 member K; CD207 molecule; Langerin; CD_antigen: CD207]
NCBI GI Number
557357745
NCBI Accession Number
NP_056532.4
NCBI GB Accession Number
NP_056532.4
Uniprot Accession Number
Q9UJ71
Available Sizes
Curated Selection
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