NRF1
Product Specifications
Gene Name
[NRF1]
NCBI Gene ID
4899
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.<br>Antibody without azide: store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK, and it regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (MAREs). A family of NF-E2 related proteins, which are collectively known as the Cap 'n' collar (CNC) family and include Nrf1 (also designated TCF11), Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind MARE sequences. The Nrf proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, JunB and JunD) to activate gene expression, specifically the detoxifying enzyme, NQO1. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1. Nrf3 is highly expressed in placenta, B cells and monocytes.
Other Gene Names
[NRF1; NRF1; ALPHA-PAL; NRF-1; Alpha-pal]
Short Name
[NRF1]
Other Product Names
[nuclear respiratory factor 1 isoform 1; Nuclear respiratory factor 1; nuclear respiratory factor 1; nuclear respiratory factor 1; Alpha palindromic-binding protein]
NCBI GI Number
93141039
NCBI Accession Number
NP_001035199.1
NCBI GB Accession Number
NP_001035199.1
Uniprot Accession Number
Q16656
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
VP 581-T 1 EACH
MICROPLATE CARRIER, use with Tecan for PCR Plates. PCR Plates are locked down to allow Robotic removal of VP 248 Disposable Pin Replicators after piercing Plate Seals, Carrier is Constructed of Aluminum with Matching Dimensions and Countersunk Mounting Holes as in a Standard Tecan Plate Carrier. The carrier has 4 perimeter rails, for each side of the Microplate, one Short Side rail has a Deep Groove or undercut to hold Plate skirt lip, the two Long side rails have shallow Grooves allowing Plates to snap into place, the last Short Side rail is beveled and has no Groove but has two small (0.25") ball-nose spring plungers to hold Plate in place, this last Short Side rail also has a Center thumb/set screw which can be used to Manually Clamp Plate after loading.
Ask
View Details