NKX3.1 (Metastatic Prostate Adenocarcinoma Marker)
Product Specifications
Gene Name
[NKX3.1]
NCBI Gene ID
4824
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.<br>Antibody without azide: store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
NKX3.1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21.2, which frequently undergoes a loss of heterozygosity. NKX3.1 expression is highly restricted in prostate epithelial cells and therefore can be used as a biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3.1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3.1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas.
Other Gene Names
[NKX3-1; NKX3-1; NKX3; BAPX2; NKX3A; NKX3.1; NKX3.1; NKX3A]
Short Name
[NKX3.1]
Other Product Names
[homeobox protein Nkx-3.1 isoform 2; Homeobox protein Nkx-3.1; homeobox protein Nkx-3.1; NK3 homeobox 1; Homeobox protein NK-3 homolog A]
NCBI GI Number
373432628
NCBI Accession Number
NP_001243268.1
NCBI GB Accession Number
NP_001243268.1
Uniprot Accession Number
Q99801
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6227703-01 0.1 mL
GABPA (GA Binding Protein Transcription Factor, alpha Subunit 60kD, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A) (MaxLight 650)
Ask
View Details MBS6227703-02 5x 0.1 mL
GABPA (GA Binding Protein Transcription Factor, alpha Subunit 60kD, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A) (MaxLight 650)
Ask
View Details 
