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MCM6 (Proliferation Marker)

Product Specifications

Gene Name

[MCM6]

NCBI Gene ID

4175

Reactivity

Human

Storage Conditions

Antibody with azide: store at 2 to 8 degree C.<br>Antibody without azide: store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Specificity

The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM6 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1/S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the post-replicative state of the cell. MCM2/MCM6 complexes function as substrates for Cdc2/cyclin B in vitro.

Other Gene Names

[MCM6; MCM6; Mis5; P105MCM; MCG40308]

Short Name

[MCM6]

Other Product Names

[DNA replication licensing factor MCM6; DNA replication licensing factor MCM6; DNA replication licensing factor MCM6; minichromosome maintenance complex component 6; p105MCM]

NCBI GI Number

2497824

NCBI Accession Number

Q14566.1

Uniprot Accession Number

Q14566

Available Sizes

Frequently Asked Questions

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