IgD (Immunoglobulin Delta Heavy Chain) (B-Cell Marker)
Product Specifications
Gene Name
[IGHD]
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.<br>Antibody without azide: store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through interchain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin D (IgD) exists as a monomer with light chains. It plays a biological role as a transmembrane receptor molecule, co-expressed with IgM on the surface of mature/naive B cells. In particular, it is found on spleen B cell surfaces. Compared to IgM, IgD exists in much lower numbers and is not expressed on immature B cells. IgD surface expression on B cells is regulated in part by IL-27. In mice, the inhibition of this immunoglobulin isotype does not cause a significant change to the immune system.
Other Gene Names
[IGHD]
Short Name
[IgD (Immunoglobulin Delta Heavy Chain)]
Other Product Names
[Ig delta chain C region; Ig delta chain C region]
NCBI GI Number
193806360
NCBI Accession Number
P01880.2
Uniprot Accession Number
P01880
Available Sizes
Curated Selection
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