MSH6 (DNA Mismatch Repair Protein)
Product Specifications
Gene Name
[MSH6]
NCBI Gene ID
2956
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.<br>Antibody without azide: store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.
Other Gene Names
[MSH6; MSH6; GTBP; HSAP; p160; GTMBP; HNPCC5; GTBP; hMSH6; GTBP; GTMBP; p160]
Short Name
[MSH6]
Other Product Names
[DNA mismatch repair protein Msh6 isoform 1; DNA mismatch repair protein Msh6; DNA mismatch repair protein Msh6; mutS homolog 6; G/T mismatch-binding protein; GTBP; GTMBP; MutS-alpha 160 kDa subunit]
NCBI GI Number
4504191
NCBI Accession Number
NP_000170.1
NCBI GB Accession Number
NP_000170.1
Uniprot Accession Number
P52701
Available Sizes
Curated Selection
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