PD-L1/PDCD1LG1/CD274/B7-H1 (Cancer Immunotherapy Target)

Product Specifications

Gene Name

[CD274]

NCBI Gene ID

29126

Reactivity

Human, Mouse

Storage Conditions

Antibody with azide: store at 4 to 8 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Specificity

PD-L1 is a checkpoint regulator in immune cells, it is expressed on immune or non-hematopoietic cells. Expression of the protein is seen during pregnancy where it has a role in suppressing the immune system. PD-L1 induces an inhibitory signal in activated T-cells and promotes T-cell apoptosis. It is overexpressed in a number of different cancers where it is believed to play a significant role in the cancer s ability to evade the immune system.

Other Gene Names

[CD274; CD274; B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1; B7H1; PDCD1L1; PDCD1LG1; PDL1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7-H1]