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Cathepsin D (Tumor Marker)

Product Specifications

Gene Name

[CTSD]

NCBI Gene ID

1509

Reactivity

Human

Storage Conditions

Antibody with azide: store at 2 to 8 degree C.<br>Antibody without azide: store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Specificity

Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43kDa preprocathepsin D that is cleaved and glycosylated to form a 46kDa procathepsin D and then further cleaved to produce 28kDa and 15kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

Other Gene Names

[CTSD; CTSD; CPSD; CLN10; HEL-S-130P; CPSD]

Short Name

[Cathepsin D]

Other Product Names

[cathepsin D preproprotein; Cathepsin D; cathepsin D; cathepsin D]

NCBI GI Number

4503143

NCBI Accession Number

NP_001900.1

NCBI GB Accession Number

NP_001900.1

Uniprot Accession Number

P07339

Available Sizes

Frequently Asked Questions

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