Cathepsin D (Tumor Marker)
Product Specifications
Gene Name
[CTSD]
NCBI Gene ID
1509
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.<br>Antibody without azide: store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43kDa preprocathepsin D that is cleaved and glycosylated to form a 46kDa procathepsin D and then further cleaved to produce 28kDa and 15kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.
Other Gene Names
[CTSD; CTSD; CPSD; CLN10; HEL-S-130P; CPSD]
Short Name
[Cathepsin D]
Other Product Names
[cathepsin D preproprotein; Cathepsin D; cathepsin D; cathepsin D]
NCBI GI Number
4503143
NCBI Accession Number
NP_001900.1
NCBI GB Accession Number
NP_001900.1
Uniprot Accession Number
P07339
Available Sizes
Curated Selection
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