CD21 (Mature B-Cell & Follicular Dendritic Cell Marker)
Product Specifications
Gene Name
[CD21]
NCBI Gene ID
1380
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.<br>Antibody without azide: store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Recognizes a protein of 140kDa, which is identified as the complement receptor 2(CR2)/CD21. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro.CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha.CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.
Other Gene Names
[CR2; CR2; CR; C3DR; CD21; CVID7; SLEB9; C3DR; Cr2; EBV receptor]
Short Name
[CD21]
Other Product Names
[Complement receptor type 2; Complement receptor type 2; complement receptor type 2; complement C3d receptor 2; Complement C3d receptor; Epstein-Barr virus receptor; EBV receptor; CD_antigen: CD21]
NCBI GI Number
215273962
NCBI Accession Number
P20023.2
Uniprot Accession Number
P20023
Available Sizes
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