CD21 (Mature B-Cell & Follicular Dendritic Cell Marker)

Product Specifications

Gene Name

[CD21]

NCBI Gene ID

1380

Reactivity

Human

Storage Conditions

Antibody with azide: store at 2 to 8 degree C.<br>Antibody without azide: store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Specificity

Recognizes a protein of 140kDa, which is identified as the complement receptor 2(CR2)/CD21. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro.CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha.CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.

Other Gene Names

[CR2; CR2; CR; C3DR; CD21; CVID7; SLEB9; C3DR; Cr2; EBV receptor]

Short Name

[CD21]

Other Product Names

[Complement receptor type 2; Complement receptor type 2; complement receptor type 2; complement C3d receptor 2; Complement C3d receptor; Epstein-Barr virus receptor; EBV receptor; CD_antigen: CD21]