MerTK (Innate Immune Checkpoint)
Product Specifications
Gene Name
[MERTK]
NCBI Gene ID
10461
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8°C.<br>Antibody without azide: store at -20 to -80°C.<br>Non-hazardous. No MSDS required.
Specificity
MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.
Other Gene Names
[MERTK; MERTK; MER; RP38; c-Eyk; c-mer; Tyro12; MER]
Short Name
[MerTK]
Other Product Names
[tyrosine-protein kinase Mer; Tyrosine-protein kinase Mer; tyrosine-protein kinase Mer; MER proto-oncogene, tyrosine kinase; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK]
NCBI GI Number
66932918
NCBI Accession Number
NP_006334.2
NCBI GB Accession Number
NP_006334.2
Uniprot Accession Number
Q12866
Available Sizes
Curated Selection
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