Cell Division Cycle 34 homolog

Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by the proteolysis of cyclins. The cell division cycle (Cdc) genes are required at various points in the cell cycle. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. Cdc6 is the human homolog of Saccharomyces cerevisiae Cdc6, which is involved in the initiation of DNA replication. Cdc37 appears to facilitate Cdk4/cyclin D1 complex formation and has been shown to form a stable complex with HSP 90. Cdc34, Cdc27 and Cdc16 function as ubiquitinconjugating enzymes. Cdc34 is thought to be the structural and functional homolog of Saccharomyces cerevisiae Cdc34, which is essential for the G1 to S phase transition. Cdc16 and Cdc27 are components of the APC (anaphasepromoting complex) which ubiquitinates cyclin B, resulting in cyclin B/Cdk complex degradation.

[ubiquitin-conjugating enzyme E2 R1; Ubiquitin-conjugating enzyme E2 R1; ubiquitin-conjugating enzyme E2 R1; cell division cycle 34; (E3-independent) E2 ubiquitin-conjugating enzyme R1 (EC:2.3.2.241 PublicationManual assertion based on experiment iniRef.20"E3-independent monoubiquitination of ubiquitin-binding proteins."Hoeller D., Hecker C.M., Wagner S., Rogov V., Doetsch V., Dikic I.Mol. Cell 26:891-898(2007) [PubMed] [Europe PMC] [Abstract]Cited for: CATALYTIC ACTIVITY AS E3-INDEPENDENT E2 UBIQUITIN-CONJUGATING ENZYME.]