Major Vault Protein (MVP)
Product Specifications
Gene Name
[MVP]
NCBI Gene ID
9961
Reactivity
Human. Others not tested.
Storage Conditions
Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
Other Gene Names
[MVP; MVP; LRP; VAULT1; LRP; MVP]
Short Name
[Major Vault Protein (MVP)]
Other Product Names
[major vault protein isoform 2; Major vault protein; major vault protein; major vault protein; Lung resistance-related protein]
NCBI GI Number
645912958
NCBI Accession Number
NP_001280133.1
NCBI GB Accession Number
NM_001293204.1
Uniprot Accession Number
Q14764
Available Sizes
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