BAP1 (BRCA1 Associated Protein 1)
Product Specifications
Gene Name
[BAP1]
NCBI Gene ID
8314
Reactivity
Human. Others not known.
Storage Conditions
Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.
Other Gene Names
[BAP1; BAP1; UCHL2; hucep-6; HUCEP-13; KIAA0272]
Short Name
[BAP1 (BRCA1 Associated Protein 1)]
Other Product Names
[ubiquitin carboxyl-terminal hydrolase BAP1; Ubiquitin carboxyl-terminal hydrolase BAP1; ubiquitin carboxyl-terminal hydrolase BAP1; BRCA1 associated protein 1; BRCA1-associated protein 1; Cerebral protein 6]
NCBI GI Number
4757836
NCBI Accession Number
NP_004647.1
NCBI GB Accession Number
NM_004656.3
Uniprot Accession Number
Q92560
Available Sizes
Curated Selection
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