What is the catalog number for Thymidylate Synthase (5-FU Resistance Marker)?

The catalog number for Thymidylate Synthase (5-FU Resistance Marker) is MBS4380708.

What sizes are available for Thymidylate Synthase (5-FU Resistance Marker)?

Thymidylate Synthase (5-FU Resistance Marker) is available in the following size(s): 0.02 mg (With BSA & Azide at 0.2mg/mL), 0.1 mg (With BSA & Azide at 0.2mg/mL), 0.1 mg (Without BSA & Azide at 1mg/mL), 5x 0.1 mg (With BSA & Azide at 0.2mg/mL), 5x 0.1 mg (Without BSA & Azide at 1mg/mL).

How many pack sizes does Thymidylate Synthase (5-FU Resistance Marker) come in?

Thymidylate Synthase (5-FU Resistance Marker) is available in 5 different pack sizes.

Is Thymidylate Synthase (5-FU Resistance Marker) in stock?

Thymidylate Synthase (5-FU Resistance Marker) is currently made to order / not held in immediate stock. Contact us for lead time.

Thymidylate Synthase (5-FU Resistance Marker)

Product Specifications

Gene Name

[TYMS]

NCBI Gene ID

7298

Reactivity

Human. Others not known.

Storage Conditions

Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Specificity

It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.