TLE1 (Synovial Sarcoma Marker)
Product Specifications
Gene Name
[TLE1]
NCBI Gene ID
7088
Reactivity
Human. Others not known.
Storage Conditions
Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Key players in the Notch pathway are the TLE genes, which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. Transducin-like enhancer protein 1 (TLE1) is a protein that is encoded by the TLE1 gene and is involved in control of hematopoiesis, neuronal, and terminal epithelial differentiation. Positive immunohistochemical nuclear staining with anti-TLE-1 has been shown to be a useful addition to an IHC panel when differentiating synovial sarcoma from other soft tissue malignancies.
Other Gene Names
[TLE1; TLE1; ESG; ESG1; GRG1; ESG1]
Short Name
[TLE1]
Other Product Names
[transducin-like enhancer protein 1 isoform 1; Transducin-like enhancer protein 1; transducin-like enhancer protein 1; transducin like enhancer of split 1; E(Sp1) homolog; Enhancer of split groucho-like protein 1; ESG1]
NCBI GI Number
733605268
NCBI Accession Number
NP_001290032.1
NCBI GB Accession Number
NM_001303103.1
Uniprot Accession Number
Q04724
Available Sizes
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