DOG-1/TMEM16A (Gastrointestinal Stromal Tumor Marker)
Product Specifications
Gene Name
[TMEM16A]
NCBI Gene ID
55107
Reactivity
Human. Others not known.
Storage Conditions
Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4% vs. 94.7%.
Other Gene Names
[ANO1; ANO1; DOG1; TAOS2; ORAOV2; TMEM16A; DOG1; ORAOV2; TAOS2; TMEM16A]
Short Name
[DOG-1/TMEM16A]
Other Product Names
[anoctamin-1; Anoctamin-1; anoctamin-1; anoctamin 1; Discovered on gastrointestinal stromal tumors protein 1; Oral cancer overexpressed protein 2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2]
NCBI GI Number
194306539
NCBI Accession Number
NP_060513.5
NCBI GB Accession Number
NM_018043.5
Uniprot Accession Number
Q5XXA6
Available Sizes
Curated Selection
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