NME2/nm23-H2/NDPK-B (Suppressor of Metastasis)

Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.

The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines, one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells. Based on sequence analysis, nm23 appears highly related to nucleotide diphosphate kinases (NDP). In humans, NDP kinases A and B are identical to two isotypes of human nm23 homologs, namely nm23-H1 and H2, respectively. nm23-H2 is identical in sequence to PuF, a transcription factor that binds to nuclease hypersensitive elements at positions 142 to 115 of the human c-Myc promotor.

[NME1-NME2 protein; Nucleoside diphosphate kinase B; NME1-NME2 protein; NME1-NME2 readthrough; C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB (EC:2.7.13.31 PublicationManual assertion based on experiment iniRef.10"Reversible histidine phosphorylation in mammalian cells: a teeter-totter formed by nucleoside diphosphate kinase and protein histidine phosphatase 1."Wieland T., Hippe H.J., Ludwig K., Zhou X.B., Korth M., Klumpp S.Methods Enzymol. 471:379-402(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION AS HISTIDINE PROTEIN KINASE.]