MMP3 (Marker of Metastasis and Rheumatoid Arthritis)
Product Specifications
Gene Name
[MMP3]
NCBI Gene ID
4314
Reactivity
Human. Others not tested.
Storage Conditions
Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, 2 and 3, respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.
Other Gene Names
[MMP3; MMP3; SL-1; STMY; STR1; CHDS6; MMP-3; STMY1; STMY1; SL-1; MMP-3]
Short Name
[MMP3]
Other Product Names
[stromelysin-1 preproprotein; Stromelysin-1; stromelysin-1; matrix metallopeptidase 3; Matrix metalloproteinase-3; MMP-3; Transin-1]
NCBI GI Number
4505217
NCBI Accession Number
NP_002413.1
NCBI GB Accession Number
NM_002422.4
Uniprot Accession Number
P08254
Available Sizes
Curated Selection
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