Kappa Light Chain/IGKC (B-Cell Marker)
Product Specifications
Gene Name
[IGKC]
NCBI Gene ID
3514
Reactivity
Human. Others not known.
Storage Conditions
Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
This MAb is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. It recognizes human Ig kappa light chains of both secreted and cell surface immunoglobulin. It detects also free kappa light chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
Other Gene Names
[IGKC; IGKV1D-16; Km; HCAK1; IGKCD]
Short Name
[Kappa Light Chain/IGKC]
Other Product Names
[Immunoglobulin kappa variable 1D-16; Immunoglobulin kappa variable 1D-16; immunoglobulin kappa constant; Ig kappa chain V-I region HK146]
NCBI GI Number
857434459
NCBI Accession Number
P01601.2
Uniprot Accession Number
P01601
Available Sizes
Curated Selection
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