EGFRvIII (Epidermal Growth Factor Receptor, Variant III)
Product Specifications
Gene Name
[EGFR]
NCBI Gene ID
1956
Reactivity
Human. Others not known.
Storage Conditions
Antibody with azide - store at 2 to 8 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
Other Gene Names
[EGFR; EGFR; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; ERBB; ERBB1; HER1]
Short Name
[EGFRvIII (Epidermal Growth Factor Receptor, Variant III)]
Other Product Names
[epidermal growth factor receptor isoform a; Epidermal growth factor receptor; epidermal growth factor receptor; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1]
NCBI GI Number
29725609
NCBI Accession Number
NP_005219.2
NCBI GB Accession Number
NM_005228.4
Uniprot Accession Number
P00533
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