CD21 (Mature B-Cell & Follicular Dendritic Cell Marker)
Product Specifications
Gene Name
[CD21]
NCBI Gene ID
1380
Reactivity
Human. Others not known.
Storage Conditions
Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Recognizes a protein of 140kDa, which is identified as the complement receptor 2 (CR2) or CD21. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.
Other Gene Names
[CR2; CR2; CR; C3DR; CD21; CVID7; SLEB9; C3DR; Cr2; EBV receptor]
Short Name
[CD21]
Other Product Names
[complement receptor type 2 isoform 1; Complement receptor type 2; complement receptor type 2; complement C3d receptor 2; Complement C3d receptor; Epstein-Barr virus receptor; EBV receptor; CD_antigen: CD21]
NCBI GI Number
54792123
NCBI Accession Number
NP_001006659.1
NCBI GB Accession Number
NM_001006658.2
Uniprot Accession Number
P20023
Available Sizes
Curated Selection
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