TLE1 (Synovial Sarcoma Marker)
Product Specifications
Gene Name
[TLE1]
NCBI Gene ID
7088
Reactivity
Human. Others not known.
Specificity
Key players in the Notch pathway are the TLE genes, which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. Transducin-like enhancer protein 1 (TLE1) is a protein that is encoded by the TLE1 gene and is involved in control of hematopoiesis, neuronal, and terminal epithelial differentiation. Positive immunohistochemical nuclear staining with anti-TLE-1 has been shown to be a useful addition to an IHC panel when differentiating synovial sarcoma from other soft tissue malignancies.
Other Gene Names
[TLE1; TLE1; ESG; ESG1; GRG1; ESG1]
Short Name
[TLE1]
Other Product Names
[transducin-like enhancer protein 1 isoform 1; Transducin-like enhancer protein 1; transducin-like enhancer protein 1; transducin like enhancer of split 1; E(Sp1) homolog; Enhancer of split groucho-like protein 1; ESG1]
NCBI GI Number
733605268
NCBI Accession Number
NP_001290032.1
NCBI GB Accession Number
NM_001303103.1
Uniprot Accession Number
Q04724
Available Sizes
Curated Selection
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