PU.1 (SPI-1) (B-Cell Marker)
Product Specifications
Gene Name
[PU.1]
NCBI Gene ID
6688
Reactivity
Human. Others not known.
Specificity
PU.1 is a member of the ETS family of transcription factors and is important for normal B-cell development. It is expressed in the myeloid lineage and in immature as well as mature B-lymphocytes, with the exception of plasma cells. PU.1 is expressed in germinal center B-cells and mantle B-cells. Various lymphomas are also positive for this marker. It is essential during early B-cell differentiation. The absence of PU.1 results in total block of B-cell development at the pre-pro stage. PU.1 plays a key role in normal myeloid differentiation, and regulates the expression of immunoglobulin and other genes that are important for B-cell development.
Other Gene Names
[SPI1; SPI1; OF; PU.1; SFPI1; SPI-1; SPI-A]
Short Name
[PU.1 (SPI-1)]
Other Product Names
[transcription factor PU.1 isoform 1; Transcription factor PU.1; transcription factor PU.1; Spi-1 proto-oncogene; 31 kDa-transforming protein]
NCBI GI Number
124028521
NCBI Accession Number
NP_001074016.1
NCBI GB Accession Number
NM_001080547.1
Uniprot Accession Number
P17947
Available Sizes
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