gp100/Melanosome/PMEL17/SILV (Melanoma Marker)
Product Specifications
Gene Name
[gp100]
NCBI Gene ID
6490
Reactivity
Human. Others not tested.
Specificity
Cytotoxic T lymphocytes (CTL s) recognize melanoma-associated antigens, which belong to three main groups. These groups include tumor-associated testis-specific antigens, melanocyte differentiation antigens and mutated or aberrantly expressed antigens, which are routinely used as markers to identify melanomas based on their binding to specific monoclonal antibodies. gp100, also designated ME20-M, ME20-S and PMEL 17, is classified as a melanocyte differentiation antigen and is expressed at low levels in normal cell lines and tissues, but is upregulated in melanocytes. gp100 is a highly glycosylated protein. It is also the product of proteolytic cleavage, which results in a secreted protein.
Other Gene Names
[PMEL; PMEL; P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E; D12S53E; PMEL17; SILV; ME20M; ME20-S; ME20S]
Short Name
[gp100/Melanosome/PMEL17/SILV]
Other Product Names
[melanocyte protein PMEL isoform 2; Melanocyte protein PMEL; melanocyte protein PMEL; premelanosome protein; ME20-M; ME20M]
NCBI GI Number
318037593
NCBI Accession Number
NP_001186982.1
NCBI GB Accession Number
NM_001200053.1
Uniprot Accession Number
P40967
Available Sizes
Curated Selection
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