Nucleophosmin (Acute Myeloid Leukemia Marker)
Product Specifications
Gene Name
[NPM1]
NCBI Gene ID
4869
Reactivity
Human. Others not tested.
Specificity
Recognizes a 33kDa glycoprotein, identified as Nucleophosmin (NPM). It is predominantly localized in the nucleus of cells in most tissues. NPM is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis. This phosphoprotein moves between the nucleus and the cytoplasm. It is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location. Mutations in this gene are associated with acute myeloid leukemia. The antibody may be a useful aid for classification of acute myeloid leukemia.
Other Gene Names
[NPM1; NPM1; B23; NPM; NPM; NPM]
Short Name
[Nucleophosmin]
Other Product Names
[nucleophosmin isoform 3; Nucleophosmin; nucleophosmin; nucleophosmin 1; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin]
NCBI GI Number
83641870
NCBI Accession Number
NP_001032827.1
NCBI GB Accession Number
NM_001037738.2
Uniprot Accession Number
P06748
Available Sizes
Curated Selection
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