MTAP (Tumor Suppressor Marker)
Product Specifications
Gene Name
[MTAP]
NCBI Gene ID
4507
Reactivity
Human. Others not known.
Specificity
Recognizes a protein of 31kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.
Other Gene Names
[MTAP; MTAP; BDMF; MSAP; DMSFH; LGMBF; DMSMFH; c86fus; HEL-249; MTA phosphorylase; MTAP; MTAPase]
Short Name
[MTAP]
Other Product Names
[S-methyl-5'-thioadenosine phosphorylase; S-methyl-5'-thioadenosine phosphorylase; S-methyl-5'-thioadenosine phosphorylase; methylthioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase]
NCBI GI Number
47132622
NCBI Accession Number
NP_002442.2
NCBI GB Accession Number
NM_002451.3
Uniprot Accession Number
Q13126
Available Sizes
Curated Selection
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