CD103/Integrin alpha E (T-Cell Lymphoma & Hairy Cell Leukemia Marker)
Product Specifications
Gene Name
[CD103]
NCBI Gene ID
3682
Reactivity
Human. Others not known.
Specificity
This MAb recognizes a protein of 150kDa, identified as CD103, which is the alpha-E integrin subunit of the heterodimeric alpha-E beta-7 (aEb7) integrin belonging to a small beta-7 integrin subfamily. CD103 is expressed on more than 95% of intraepithelial CD8+ cells and on 40% of mucosa-associated T cells, whereas less than 2% of resting blood lymphocytes are CD103-positive. In several malignant conditions, such as T-cell lymphomas and hairy cell leukemia (HCL), the cells express CD103. Antibody to CD103 is an extremely useful addition to the IHC panel for the hairy cell leukemia (HCL).
Other Gene Names
[ITGAE; ITGAE; CD103; HUMINAE]
Short Name
[CD103/Integrin alpha E]
Other Product Names
[integrin alpha-E; Integrin alpha-E; integrin alpha-E; integrin subunit alpha E; HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; CD_antigen: CD103]
NCBI GI Number
148728188
NCBI Accession Number
NP_002199.3
NCBI GB Accession Number
NM_002208.4
Uniprot Accession Number
P38570
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