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CD25/ IL2RA (Activated Lymphocyte Marker)

Product Specifications

Gene Name

[CD25]

NCBI Gene ID

3559

Reactivity

Human. Others not tested.

Specificity

Recognizes a protein of 55kDa, identified as CD25.It is expressed on activated T- and B-cells and activated monocytes/macrophages.With respect to lymphomas, CD25 is present on malignant cells of Hodgkins disease, HTLV-1+ adult T-cell leukemia, cutaneous T-cell lymphoma, and hair cell leukemia. Increased levels of soluble CD25 are observed in the leukemias/lymphomas and inflammatory/ autoimmune diseases. CD25 molecule alone appears to function as a low affinity receptor and associates with CD122 (IL-2R  chain, p75) and CD132 (common chain) to form the high affinity IL-2 receptor complex.CD25 antibodies detect three epitope regions, A, B and C. This MAb recognizes the epitope B, which is located at residue 3-104 of CD25 and doe not block IL-2 binding to CD25.

Other Gene Names

[IL2RA; IL2RA; p55; CD25; IL2R; IMD41; TCGFR; IDDM10; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA]

Short Name

[CD25/ IL2RA]

Other Product Names

[interleukin-2 receptor subunit alpha isoform 1; Interleukin-2 receptor subunit alpha; interleukin-2 receptor subunit alpha; interleukin 2 receptor subunit alpha; TAC antigen; p55; CD_antigen: CD25]

NCBI GI Number

4557667

NCBI Accession Number

NP_000408.1

NCBI GB Accession Number

NP_000408.1

Uniprot Accession Number

P01589

Available Sizes

Frequently Asked Questions

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