GAD1/GAD67 (GABAergic Neuronal Marker)
Product Specifications
Gene Name
[GAD1]
NCBI Gene ID
2571
Reactivity
Human
Storage Conditions
Store at -20°C to -80°C. Non hazardous. No MSDSrequired.
Specificity
This MAb recognizes a protein of 67kDa, which is identified as glutamic acid decarboxylase 1 (GDA1). There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD65 (also known as GAD2) and GAD67 (also known as GAD1. GAD65 and GAD67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate-limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD65 localizes to synaptic vesicle membranes in nerve terminals, while GAD67 is distributed throughout the cell. GAD67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD65 will transiently activate to assist in GABA production. The loss of GAD65 is detrimental and can impair GABA neurotransmission, however the loss of GAD67 is lethal.
Other Gene Names
[GAD1; GAD1; GAD; SCP; CPSQ1; GAD; GAD67; GAD-67]
Short Name
[GAD1/GAD67]
Other Product Names
[glutamate decarboxylase 1 isoform GAD67; Glutamate decarboxylase 1; glutamate decarboxylase 1; glutamate decarboxylase 1; 67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform]
NCBI GI Number
58331246
NCBI Accession Number
NP_000808.2
NCBI GB Accession Number
NM_000817.2
Uniprot Accession Number
Q99259
Available Sizes
Curated Selection
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