Cdk1/p34cdc2 Serine-Threonine Kinase
Product Specifications
Gene Name
[Cdk1]
NCBI Gene ID
983
Reactivity
Human, Mouse, Rat, Guinea Pig, Woodchuck, Xenopus, Chicken. Others not known.
Storage Conditions
Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Recognizes a 34kDa protein (cdk1), identified as p34cdc2 (a catalytic subunit of Maturation Promoting Factor). Its epitope maps near the C-terminus of the protein and its core is thought to be LGTPNNEV (aa220-227 in murine cdc2). It shows no cross reaction with cdk2 p32. It supports the kinase activity. p34cdc2 plays a crucial role during cell division and is most active during mitosis. It is a serine/threonine kinase, which is activated by cyclin, by dephosphorylation of tyrosine residues. p34cdc2 is inactivated by a tyrosine kinase. This MAb reportedly inhibits the activation of p34cdc2 kinase by cyclins.
Other Gene Names
[CDK1; CDK1; CDC2; CDC28A; P34CDC2; CDC2; CDC28A; CDKN1; P34CDC2; CDK1]
Short Name
[Cdk1/p34cdc2 Serine-Threonine Kinase]
Other Product Names
[cyclin-dependent kinase 1 isoform 1; Cyclin-dependent kinase 1; cyclin-dependent kinase 1; cyclin dependent kinase 1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase]
NCBI GI Number
1004170672
NCBI Accession Number
NP_001307847.1
NCBI GB Accession Number
NM_001320918.1
Uniprot Accession Number
P06493
Available Sizes
Curated Selection
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