CD22/BL-CAM (B-Cell Marker)
Product Specifications
Gene Name
[CD22]
NCBI Gene ID
933
Reactivity
Human. Others not known.
Storage Conditions
Antibody without azide - store at -20°C to -80°C.<br> Non-hazardous. No MSDS required.
Specificity
Recognizes a protein of 130-140kDa, identified as CD22 (also known as BL-CAM). CD22 expression is restricted to normal and neoplastic B cells and is absent from other haemopoietic cell types. In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. It is not expressed by plasma cells, CD22 is found highly expressed in follicular mantle and marginal zone B-cells, and while germinal center B-cells are relatively weak. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation.
Other Gene Names
[CD22; CD22; SIGLEC2; SIGLEC-2; SIGLEC2; BL-CAM; Siglec-2]
Short Name
[CD22/BL-CAM]
Other Product Names
[B-cell receptor CD22 isoform 2; B-cell receptor CD22; B-cell receptor CD22; CD22 molecule; B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD_antigen: CD22]
NCBI GI Number
297374825
NCBI Accession Number
NP_001172028.1
NCBI GB Accession Number
NM_001185099.1
Uniprot Accession Number
P20273
Available Sizes
Curated Selection
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