PAX8 (Renal Cell Marker)
Product Specifications
Gene Name
[PAX8]
NCBI Gene ID
7849
Reactivity
Human. Others not known.
Storage Conditions
Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Recognizes a protein of 62kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.
Other Gene Names
[PAX8; PAX8]
Short Name
[PAX8]
Other Product Names
[paired box protein Pax-8 isoform PAX8A; Paired box protein Pax-8; paired box protein Pax-8; paired box 8]
NCBI GI Number
5803117
NCBI Accession Number
NP_003457.1
NCBI GB Accession Number
NM_003466.3
Uniprot Accession Number
Q06710
Available Sizes
Curated Selection
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