Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker)

Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.

It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

[5,6-dihydroxyindole-2-carboxylic acid oxidase; 5,6-dihydroxyindole-2-carboxylic acid oxidase; 5,6-dihydroxyindole-2-carboxylic acid oxidase; tyrosinase related protein 1; Catalase B; Glycoprotein 75]