TSH-Receptor, B-Chain (Thyroid Marker)
Product Specifications
Gene Name
[TSHR]
NCBI Gene ID
7253
Reactivity
Human. Others not known.
Storage Conditions
Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.
Other Gene Names
[TSHR; TSHR; LGR3; CHNG1; hTSHR-I; LGR3; TSH-R]
Short Name
[TSH-Receptor]
Other Product Names
[thyrotropin receptor isoform 1; Thyrotropin receptor; thyrotropin receptor; thyroid stimulating hormone receptor; Thyroid-stimulating hormone receptor; TSH-R]
NCBI GI Number
64085121
NCBI Accession Number
NP_000360.2
NCBI GB Accession Number
NM_000369.2
Uniprot Accession Number
P16473
Available Sizes
Curated Selection
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