TTF-1/NKX2.1 (Thyroid & Lung Epithelial Marker)
Product Specifications
Gene Name
[TTF-1]
NCBI Gene ID
7080
Reactivity
Human, Mouse, Rat. Others not known.
Storage Conditions
Antibody with azide - store at 2-8°C<br>Antibody is stable for 24 months. <br>Non-hazardous.<br> No MSDS required.
Specificity
Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.
Other Gene Names
[NKX2-1; NKX2-1; BCH; BHC; NK-2; TEBP; TTF1; NKX2A; NMTC1; T/EBP; TITF1; TTF-1; NKX2.1; TTF-1; T/EBP]
Short Name
[TTF-1/NKX2.1]
Other Product Names
[homeobox protein Nkx-2.1 isoform 1; Homeobox protein Nkx-2.1; homeobox protein Nkx-2.1; NK2 homeobox 1; Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1; TTF-1; Thyroid-specific enhancer-binding protein; T/EBP]
NCBI GI Number
118766339
NCBI Accession Number
NP_001073136.1
NCBI GB Accession Number
NM_001079668.2
Uniprot Accession Number
P43699
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