Bcl-2 (Apoptosis& Follicular Lymphoma Marker)
Product Specifications
Gene Name
[Bcl-2]
NCBI Gene ID
596
Reactivity
Human. Others not known.
Storage Conditions
Antibody with azide - store at 2 to 8 degree C.<br>Antibody without azide - store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
This antibody recognizes a protein of 25-26kDa, identified as the bcl-2 lpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 lpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 lpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.
Other Gene Names
[BCL2; BCL2; Bcl-2; PPP1R50]
Short Name
[Bcl-2]
Other Product Names
[apoptosis regulator Bcl-2 isoform alpha; Apoptosis regulator Bcl-2; apoptosis regulator Bcl-2; BCL2, apoptosis regulator]
NCBI GI Number
72198189
NCBI Accession Number
NP_000624.2
NCBI GB Accession Number
NM_000633.2
Uniprot Accession Number
P10415
Available Sizes
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